Endocrine Abstracts

Several studies have pointed to increased morbidity and mortality in patients with hypopituitarism, particularly from cardiovascular diseases, regardless of the application of the substitution therapy. The aim of this study was to present clinical characteristics and cardiovascular risk of our patients with hypopituitarism during 20 years of follow-up.Methods: Sixty patients with hypopituitarism without patients with acromegaly and Cushing disease were a...

Primary hyperparathyroidism is an autonomous form of hyperparathyroidism, whose characteristics are: increased secretion of parathyroid hormone with clinical signs of hypercalcemic syndrome and various organ lesions, including bones.Case report: A 51-year-old Caucasian female presented with walking difficulties, polyuria, polydipsia, palpitations and headaches. Examination showed thoracic spine hyperkyphosis with consecutive chest deformity, staggered wa...

Metabolic and immunological disturbances may be associated with hyperprolactinemia.Aim: The aim of this study was examination the presence of some metabolic and immunological disturbances, like as the changes in and body composition, as risk factors for development of atherosclerosis, in young women with hyperprolactinemia.Material and methods: The investigation was performed as prospective study in a group of 20 premenopausal wome...

Adrenal tumours form a very heterogeneous group by their origin, clinical presentation, size and biological potential.The aim of our retrospective study was the epidemiological analysis of the patients with adrenal tumours. We analyzed the gender, age, localisation, clinical presentation, and in patients who were treated surgically- the type of the intervention, patohystological and immunohystochemical finding from the 01.01.2000 to 01.01.2008. The linea...

Background and aims: Foot lesions (amputations, ulcerations) are the consequence of neuro-vascular complications. Cardiovascular risk factors are similar for both. Thus, we carried out a prospective 5-year study to examine the effects of established complications and classical risk factors on mortality in diabetic patients.Materials and methods: During the previous 5 years we analyzed 244 patients attending a diabetes clinic. The International Working Gr...

Introduction: L thyroxin treatment of CH is monitored by free T4 (fT4) which should be above mid normal range for the assay. It is not clear whether these doses are adequate for regulating the metabolic disturbances accompanying CH.Aim: To determine whether T4 therapy leads to improvement of metabolic parameters in CH.Materials and methods: This was a retrospective study. Study group comprised of 60 hypopituitary patients with CH, ...

Introduction: Biological casuses of levothyroxine (LT4) malabsorption are well known. Congestive heart failure, gastrointestinal diseases, pregnancy, medication or dietary interference are the most commonly known causes of poor oral absorption of LT4. However, when substitution therapy with LT4 fails we need to be more exploratory.Case description: Female, born in 1987, BH 164 cm, BW 73kg, in 2010 she was presented as M. Basedowi and in october 2011 near...

Introduction: The impairment of liver function and enhancement for NAFLD development may be attributed to the ubiquitous exposure to endocrine disrupting chemicals such as phthalates. In this study the urinary levels of monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) were compared with the parameters of hepatic function and lipids in overweight, diabetic patients and normal weight population.Methods and patients: In 305 volunteers of b...

Introduction: Congentital adrenal hyperplasia (CAH) comes to adult endocrinologist wheather as transition from pediatritian (Case 3) or as still without diagnosis (Case 1, 2, 4). The aim of this work is to describe typical forms of CAH initially sucessfuly treated with dexamethasone therapy.Case descriptions: Case 1: female, 1972y., presented in 1995y. (23y.) as severe hirsutism and infertility managed by team of gynecologists. She refus...

Introduction: It is indisputable importance of vitamin D for the preserved integrity of the skeleton and bone metabolism.The aim of the study was to analyse bone turnover parameters in relation to the vitamin D status in women with postmenopausal osteoporosis.Materials and methods: This study included a total of 195 postmenopausal women with osteoporosis. Osteoporosis is diagnosed by DXA scan of the spine and hip. Bone turnover mar...